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Presentation
The Multimodal Imaging Center (MIC) was created on 1 January 2020 by the four trustees, the CNRS, the Inserm, the Institut Curie, and Université Paris-Saclay, as a service unit UAR2016/ US43.
The MIC Unit brings together the expertise of Imaging (Light Microscopy, Electron cryo-Microscopy, Ionic Microscopy, Image Processing and Analysis) and makes available to the scientific, academic and industrial community a service offering, training and R&D in multimodal imaging.
Our service unit, with an integrated vision, offers targeted activities around multi-scale and multimodal imaging on different types of samples (molecules, cells and tissues).
These activities are divided into 4 poles of expertise around sub-cellular and correlative imaging, chemical mapping of multiplexing and analysis and processing of generated images.
Unit Governance :
The Director relies on several committees to manage the unit.
The Committee of Trustees decides on the main scientific, technological and organisational guidelines, in relation to the geographical context
The strategic policy committee defines priorities, ensures the quality of services offered and proposes methodological developments
Each pole user committee make possible to take collective decisions on the operation and management of the pole and to make proposals for strategic direction
Members
Former team members
- Antoine Cossa (2018-2022), PhD Student
- Noémie Bozier (2025), Research trainee
- Lisa Garrigos (2025), Research trainee
- Kamenan N'Gadi (2024), Research trainee
- Rayane Bennani (2024), Research trainee
- Arthus Georgelin (2023), Research trainee
- Sylvain Trépout (IR2 Inserm, 2022), Research engineer
- Camille Rabier (2022), Research trainee
- Anthony Boutard (2022), Research trainee
- Ptissam Bergam (IECN CNRS, 2021), Engineer
- Thomas El Khilali (2021), Research trainee
- Typhaine Rumiac (2021), Research trainee
- Jean-Luc Guerquin-Kern (CRHC Inserm, 2020) , Research Officer
- Amandine Dumazel (2020), Research trainee
- Rayane Serir (2020), Research trainee
Publications
Cancer Cell - 01/02/2026
See authors
Proc Natl Acad Sci U S A - 22/09/2025
Current Biology - 17/04/2025
Astronomy & Astrophysics - 23/05/2025
Neuro-Oncology - 08/07/2025
Communications Engineering - 11/08/2025
Annals of the Rheumatic Diseases - 01/05/2025
See authors
Life of the team
Image Processing and Analysis (IPA)
Université Paris-Saclay Videos
“At the Heart of Artificial Intelligence”
Two members of the Image Processing and Analysis division of the Multimodal Imaging Center were recently featured: Cédric Messaoudi and Noémie Bozier. They took part in the filming of a video produced as part of the exhibition “At the Heart of Artificial Intelligence (AI)”, organized by Université Paris-Saclay.
Through this video series, you will discover how the University’s teams are contributing to major breakthroughs in a wide range of fields, including healthcare, energy, the humanities, industry, and the environment. The videos highlight how AI is shaping our daily lives and sustainably transforming the way we live and work.
Don’t miss Video No. 7, dedicated to the IPA team, for an inspiring immersion into the heart of imaging and artificial intelligence.
Whole Unit
Medical and scientific day (JSM)
12/12/2025 Institut Curie-Paris
At JSM 2025, on the initiative of the Institut Curie Events Department, a series of short videos was screened throughout the day to highlight the Institute’s staff. In this context, Christine Walczak, an Inserm engineer in the Image Processing and Analysis pole, presented her professional career and the key topics she is involved in, thereby helping to promote the work of the Multimodal Imaging Center.
Whole unit
Continuing education
As part of a Professional Bachelor's Degree (L3) in Bio-industries and Biotechnology, our unit welcomed five interns—Oumaïma Bouchaqour, Lisa Garrigos, Rana Hajji, Lou Lacam, and Donia Mocho—from January 13 to 24, 2025.
This year, we assigned the students a project on selecting the most suitable membrane fluorescent probe for automatically outlining cell contours. After receiving both theoretical and practical training on microscopes, they were introduced to image processing and formatting using the Fiji software. Their results were presented at the end of the internship before a jury composed of internal and external members of the unit.
Electron Microscopy
Workshop
Cédric Messaoudi participated in the electron microscopy workshop as part of the GAP doctoral network, a European Marie Sklodowska-Curie project (https://www.gapmscaproject.com) focused on "biomineralization" and the structure of bone systems.
This workshop took place in Strasbourg from December 2 to 3, 2024. Cédric delivered a theoretical and practical course on electron tomography reconstruction.
The UAR2016/US43 unit: an offer of services
Light Microscopy Facility
The Light microscopy pole consists of 2 engineers:
Marie-Noëlle Soler (manager, research engineer)
Laetitia Besse (technical engineer)
The facility combines highly sophisticated equipment and advanced microscopy technologies. Its main objective is to provide the research teams of the Institut Curie and external users (academic and private) with imaging approaches at different scales and complementary methods, allowing the imaging of molecules, organelles, cells, whole organisms and tissues in healthy and pathological states.
Ten light imaging systems are installed in the facility: 3 wide-field microscopes, 3 videomicroscopes (including an IncuCyte system), 2 conventional confocal laser scanning microscopes, one equipped with a pulsed infrared laser (for photomanipulations and fluorescence lifetime measurement) and the other equipped with a white laser, and 2 confocal fast systems (Nipkow disks). Super-resolution module, evanescent wave imaging (azimuthal TIRF) and light sheet imaging are available on these fast confocal. FRAP is available in confocal and TIRF mode, regardless of the confocal system. The light microscopy facility is used annually by nearly 100 users, representing over 12,000 hours of acquisition.
The light microscopy facility has expertise in dynamic imaging and advanced microscopy techniques (F-techniques, super-resolution, lifetime microscopy, optogenetic tools, etc.). The following figure shows the different applications and techniques available on the platform.
The engineers organize and participate in many training courses throughout the year. These courses are organized either through the Training Unit of Institut Curie, or through the CNRS (IFSEM and CNRS Formation Entreprises), the universities (Paris Diderot, Paris-Saclay), or the microscopy networks (RTmfm, GdR Imabio).
Equipments
Ion Microscopy (NanoSIMS) Facility
The Ion Microscopy facility is coordinated by Ting-Di Wu (research engineer).
The activity of the facility is centered around a scanning ion microprobe from CAMECA, the NanoSIMS-50, an instrument designed for the analysis of specimens with fine structures and with heterogeneous chemical composition.
This instrument allows the detection of several elements or isotopes in parallel, with a lateral resolution down to 50-nm. It offers remarkable applications in different domains as biology (subcellular imaging, microbiology) and cosmochemistry (analysis of interplanetary dusts, micrometeorites).
SIMS technique (Secondary Ion Mass Spectrometry) explores the ion emission from a surface bombarded by an energetic primary ion beam.
The secondary ions emitted from the target keep the characteristic of the chemical composition of the sampled area. Thus, thanks to the combination with a mass spectrometer insuring the separation of collected ions, the SIMS technique is one of the rare methods offering the identification of elemental and isotopic information (including light elements as Hydrogen) in situ.
As the primary ion beam can be focused to a small probe, then high lateral resolution elemental and isotopic mapping can be carried out, by stepping the probe across the sample surface.
One of the features of the SIMS technique is its high sensitivity by using reactive primary ions as O–, O2+ or Cs+ which enhance the secondary ion emission. However, the quantification of elemental concentration remains difficult except in special cases. Nevertheless, the measurement of isotopic ratio can be performed at high precision.
Due to the sputtering of the sample surface, the SIMS technique is a destructive method. Fortunately, by sampling layer by layer, an analysis can offer insight into the 3D structure of the specimen surface.
Example of application in biology:
Below is the result from a collaboration with CNRS and University of Toulouse on the simultaneous visualisation of the Mycobacterium tuberculosis location and the assimilation of 15N-labelled Asparagine by these pathogens inside the host cell (macrophage). For more detail, see Gouzy A. et al (2014).
Explore further :
Electron Cryo-Microscopy Facility
The Cryo-Electron Microscopy facility is coordinated by Naoji Yubuki (research engineer) and equipped with a transmission electron microscope and EM processing equipment (including two plunge freezers and an ultramicrotome). Our facility provides researchers with top-tier electron microscopy infrastructure for advanced sample preparation, including cryo-preparation for electron microscopy, cryo-EM, and TEM tomography.
We have all the equipment necessary for the freezing of purified samples (proteins, lipids, polymers, and nanoparticles), as well as prokaryotes and unicellular eukaryotes.
Cryo observation is possible thanks to two Gatan 626 cryo-holders and a JEM 2200FS (FEG @ 200 kV) electron microscope equipped with a cryo-box. TEM imaging are facilitated by a CCD US1000 Gatan camera and a K2 Summit Gatan direct electron detector camera.
The microscope is also equipped with an in-column Omega energy filter for EFTEM acquisitions (zero-loss and energy-loss) and EELS spectroscopy.
Image Processing and Analysis
The Image Processing and Analysis group is staffed with 3 engineers:
Cédric Messaoudi (Manager, research engineer)
Laetitia Besse (technical engineer)
Christine Walczak (technical engineer)
The group’s expertise is in the analysis of images produced by light microscopy, electron microscopy and/or ion microscopy. We help users to find the best approaches to extract data from images.
Requests are studied after data acquisition or preferably during fine-tuning of experiments.
We offer:
Training on existing solutions: ImageJ/Fiji macros or plugins, but also on other software such as QuPath or Imaris.
Developing specific and customized analyses: ImageJ/Fiji macro or plugin, python scripts.
Acknowledgements
How to cite us in a publication ?
For the light microscopy pole:
The authors acknowledge the Light Microscopy facility from the Multimodal Imaging Center of the Institut Curie (CNRS UAR2016/ Inserm US43/ Institut Curie / Université Paris-Saclay).
Another version with the engineers' names:
The authors acknowledge facility engineers, Marie-Noëlle Soler and Laetitia Besse from the Multimodal Imaging Center of the Institut Curie (CNRS UAR2016/ Inserm US43/ Institut Curie / Université Paris-Saclay) for their help provided and expertise in light microscopy.
For the ion microscopy pole:
The authors acknowledge the Ion Microscopy facility from the Multimodal Imaging Center of the Institut Curie (CNRS UAR2016/ Inserm US43/ Institut Curie / Université Paris-Saclay).
Another version with the engineers' names:
The authors acknowledge facility engineer, Ting-Di Wu from the Multimodal Imaging Center of the Institut Curie (CNRS UAR2016/ Inserm US43/ Institut Curie / Université Paris-Saclay) for his help provided and expertise in ion microscopy.
For the cryo-electron microscopy pole:
The authors acknowledge the Cryo-Electron Microscopy facility from the Multimodal Imaging Center of the Institut Curie (CNRS UAR2016/ Inserm US43/ Institut Curie / Université Paris-Saclay).
Another version with the engineers' names:
The authors acknowledge facility engineer, Naoji Yubuki from the Multimodal Imaging Center of the Institut Curie (CNRS UAR2016/ Inserm US43/ Institut Curie / Université Paris-Saclay) for his help provided and expertise in (cryo-)electron microscopy.
For the Image Processing and Analysis pole:
The authors acknowledge the Image Processing and Analysis facility from the Multimodal Imaging Center of the Institut Curie (CNRS UAR2016/ Inserm US43/ Institut Curie / Université Paris-Saclay).
Another version with the engineers' names:
The authors acknowledge facility engineers, Cédric Messaoudi, Laetitia Besse and Christine Walczak from the Multimodal Imaging Center of the Institut Curie (CNRS UAR2016/ Inserm US43/ Institut Curie / Université Paris-Saclay) for useful advices on image processing.
Acknowledgements in publications
2024
Thoracic Proton Minibeam Radiation Therapy: Tissue Preservation and Survival Advantage Over Conventional Proton Therapy. Bertho A, Ortiz R, Maurin M, Juchaux M, Gilbert C, Espenon J, Ramasamy G, Patriarca A, De Marzi L, Pouzoulet F, Prezado Y. Int J Radiat Oncol Biol Phys. 2024 Oct 1;120(2):579-592.
The significance of dose heterogeneity on the anti-tumor response of minibeam radiation therapy. Potiron S, Iturri L, Juchaux M, Espenon J, Gilbert C, McGarrigle J, Ortiz Catalan R, Fernandez-Rodriguez A, Sebrié C, Jourdain L, De Marzi L, Créhange G, Prezado Y. Radiother Oncol. 2024 Oct 10;201:110577.
The AsiDNA™ decoy mimicking DSBs protects the normal tissue from radiation toxicity through a DNA-PK/p53/p21-dependent G1/S arrest. Sesink A, Becerra M, Ruan JL, Leboucher S, Dubail M, Heinrich S, Jdey W, Petersson K, Fouillade C, Berthault N, Dutreix M, Girard PM. NAR Cancer. 2024 Mar 12;6(1):zcae011.
2023
Degradable polyisoprene by radical ring-opening polymerization and application to polymer prodrug nanoparticles. Lages, M., Pesenti, T., Zhu, C., Le, D., Mougin, J., Guillaneuf, Y. and Nicolas, J., 2023. Chemical Science, 14(12), pp.3311-3325.
Tubulin polyglutamylation differentially regulates microtubule‐interacting proteins. Mariya Genova, Lenka Grycova, Verena Puttrich, Maria M Magiera, Zdenek Lansky, Carsten Janke, Marcus Braun. The EMBO Journal, 10.15252/embj.2022112101, 42, 5, (2023)
53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication. Melissa Leriche, Clara Bonnet, Jagannath Jana, Gita Chhetri, Sabrina Mennour, Sylvain Martineau, Vincent Pennaneach, Didier Busso, Xavier Veaute, Pascale Bertrand, Sarah Lambert, Kumar Somyajit, Patricia Uguen, Stéphan Vagner. Cell Reports, Volume 42, Issue 11, 2023, 113412, ISSN 2211-1247.
Anti-Cancer and Radio-Sensitizing Properties of New Bimetallic (<i>N</i>-Heterocyclic Carbene)-Amine-Pt(II) Complexes. Tao Jia, Oumar Diane, Deepanjan Ghosh, Myriem Skander, Gaelle Fontaine, Pascal Retailleau, Joël Poupon, Jérôme Bignon, Ytabelle Maga Moulai Siasia, Vincent Servajean, Nathalie Hue, Jean-François Betzer, Angela Marinetti, Sophie Bombard. Journal of Medicinal Chemistry, (2023 mai 16).
Lung Organotypic Slices Enable Rapid Quantification of Acute Radiotherapy Induced Toxicity. Dubail, M.; Heinrich, S.; Portier, L.; Bastian, J.; Giuliano, L.; Aggar, L.; Berthault, N.; Londoño-Vallejo, J.-A.; Vilalta, M.; Boivin, G.; et al. Cells 2023, 12, 2435
An interactive murine single-cell atlas of the lung responses to radiation injury. Curras-Alonso S, Soulier J, Defard T, Weber C, Heinrich S, Laporte H, Leboucher S, Lameiras S, Dutreix M, Favaudon V, Massip F, Walter T, Mueller F, Londoño-Vallejo JA, Fouillade C. Nat Commun. 2023 Apr 28;14(1):2445.
Ultrabright two-photon excitable red-emissive fluorogenic probes for fast and wash-free bioorthogonal labelling in live cells. Auvray M, Naud-Martin D, Fontaine G, Bolze F, Clavier G, Mahuteau-Betzer F. Chem Sci. 2023 Jul 4;14(30):8119-8128.
Replication gap suppression depends on the double-strand DNA binding activity of BRCA2. Vugic D, Dumoulin I, Martin C, Minello A, Alvaro-Aranda L, Gomez-Escudero J, Chaaban R, Lebdy R, von Nicolai C, Boucherit V, Ribeyre C, Constantinou A, Carreira A. Nat Commun. 2023 Jan 27;14(1):446.
2022
Photo-triggerable liposomes based on lipid-porphyrin conjugate and cholesterol combination: Formulation and mechanistic study on monolayers and bilayers. Massiot, J., Abuillan, W., Konovalov, O. and Makky, A., 2022. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1864(1), p.183812.
Degradable vinyl copolymer nanoparticles/latexes by aqueous nitroxide-mediated polymerization-induced self-assembly. Lages, M., Gil, N., Galanopoulo, P., Mougin, J., Lefay, C., Guillaneuf, Y., Lansalot, M., D’agosto, F. and Nicolas, J., 2022. Macromolecules, 55(21), pp.9790-9801.
PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma. Sittewelle M, Kappès V, Zhou C, Lécuyer D, Monsoro-Burq AH. Life Sci Alliance. 2022 Aug 1;5(12):e202201377.
Tyro3 Targeting as a Radiosensitizing Strategy in Bladder Cancer through Cell Cycle Dysregulation. Silina L, Dufour F, Rapinat A, Reyes C, Gentien D, Maksut F, Radvanyi F, Verrelle P, Bernard-Pierrot I, Mégnin-Chanet F. Int J Mol Sci. 2022 Aug 4;23(15):8671.
Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma. Maïlys Rossi, Julie Talbot, Patricia Piris, Marion Le Grand, Marie-Pierre Montero, et al. EBioMedicine, 2022, 82 (7), pp.104149.
Convergent and Practical Synthesis of Fluorescent Triphenylamine Derivatives and Their Localization in Living Cells. R. Mougeot, S. Oger, M. Auvray, T. Gallavardin, S. Leleu, F. Mahuteau-Betzer, X. Franck, Eur. J. Org. Chem. 2022, e202101397.
Cellular Detection of a Mitochondria Targeted Brominated Vinyl Triphenylamine Optical Probe (TP-Br) by X-Ray Fluorescence Microscopy. Nagarajan S, Poyer F, Fourmois L, Naud-Martin D, Medjoubi K, Somogyi A, Schanne G, Henry L, Delsuc N, Policar C, Bertrand HC, Mahuteau-Betzer F. Chemistry. 2022 Mar 10;28(15):e202104424.
Acridine-O6-benzylguanine hybrids: Synthesis, DNA binding, MGMT inhibition and antiproliferative activity. Franco Pinto J, Fillion A, Duchambon P, Bombard S, Granzhan A. Eur J Med Chem. 2022 Jan 5;227:113909.
Inhibition of DNA Repair by Inappropriate Activation of ATM, PARP, and DNA-PK with the Drug Agonist AsiDNA. Berthault, N.; Bergam, P.; Pereira, F.; Girard, P.-M.; Dutreix, M. Cells 2022, 11, 2149
The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors. Bartl, J., Zanini, M., Bernardi, F. et al. Nat Commun 13, 4061 (2022).
On the Road Toward More Efficient Biocompatible Two-Photon Excitable Fluorophores. Auvray M, Bolze F, Naud-Martin D, Poulain M, Bossuat M, Clavier G, Mahuteau-Betzer F. Chemistry. 2022 Mar 7;28(14):e202104378.
2021
Synthesis and supramolecular arrangement of new stearoyl acid-based phenalenone derivatives. Godard, J., Chapron, D., Bregier, F., Rosilio, V. and Sol, V., 2021. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 612, p.125988
Gemcitabine lipid prodrugs: the key role of the lipid moiety on the self-assembly into nanoparticles. Coppens, E., Desmaële, D., Mougin, J., Tusseau-Nenez, S., Couvreur, P. and Mura, S., 2021. Chemistry, 32(4), pp.782-793
Gemcitabine lipid prodrug nanoparticles: Switching the lipid moiety and changing the fate in the bloodstream. Coppens, E., Desmaële, D., Naret, T., Garcia-Argote, S., Feuillastre, S., Pieters, G., Cailleau, C., Paul, J.L., Prost, B., Solgadi, A. and Michel, J.P., 2021. International Journal of Pharmaceutics, 609, p.121076.
BrdU immuno-tagged G-quadruplex ligands: a new ligand-guided immunofluorescence approach for tracking G-quadruplexes in cells. Thibaut Masson, Corinne Landras Guetta, Eugénie Laigre, Anne Cucchiarini, Patricia Duchambon, Marie-Paule Teulade-Fichou, Daniela Verga. Nucleic Acids Research, Volume 49, Issue 22, 16 December 2021, Pages 12644–12660,
BMP Signaling Is Enhanced Intracellularly by FHL3 Controlling WNT-Dependent Spatiotemporal Emergence of the Neural Crest. Alkobtawi, Mansour, Patrick Pla, et Anne H. Monsoro-Burq. Cell Reports 35, no 12 (22 juin 2021): 109289.
BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair. Sessa G, Gómez-González B, Silva S, Pérez-Calero C, Beaurepere R, Barroso S, Martineau S, Martin C, Ehlén Å, Martínez JS, Lombard B, Loew D, Vagner S, Aguilera A, Carreira A. EMBO J. 2021 Apr 1;40(7):e106018.
Rrp1 translocase and ubiquitin ligase activities restrict the genome destabilising effects of Rad51 in fission yeast. Muraszko J, Kramarz K, Argunhan B, Ito K, Baranowska G, Kurokawa Y, Murayama Y, Tsubouchi H, Lambert S, Iwasaki H, Dziadkowiec D. Nucleic Acids Res. 2021 Jul 9;49(12):6832-6848.
BRN2 is a non-canonical melanoma tumor-suppressor. Hamm, M., Sohier, P., Petit, V. et al. Nat Commun 12, 3707 (2021).
Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. Gadadhar S, Alvarez Viar G, Hansen JN, Gong A, Kostarev A, Ialy-Radio C, Leboucher S, Whitfield M, Ziyyat A, Touré A, Alvarez L, Pigino G, Janke C. Science. 2021 Jan 8;371(6525):pii: eabd4914.
Modulation of cellular fate of vinyl triarylamines through structural fine tuning: to stay or not to stay in the mitochondria? Laura Fourmois, Florent Poyer, Aude Sourdon, Delphine Naud-Martin, Sounderya Nagarajan, et al. ChemBioChem, 2021, 22 (14), pp.2457-2467.
Distinct roles of α- and β-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration. Bodakuntla S, Yuan X, Genova M, Gadadhar S, Leboucher S, Birling MC, Klein D, Martini R, Janke C, Magiera MM. EMBO J. 2021 Sep 1;40(17):e108498.
Silafluorene as a promising core for cell-permeant, highly bright and two-photon excitable fluorescent probes for live-cell imaging. Marie Auvray, Frederic Bolze, Gilles Clavier, Florence Mahuteau-Betzer. Dyes and Pigments 187 (2021) 109083
A role for Dynlt3 in melanosome movement, distribution, acidity and transfer. Aktary, Z., Conde-Perez, A., Rambow, F. et al. Commun Biol 4, 423 (2021).
2020
Assessment of various formulation approaches for the application of beta-lapachone in prostate cancer therapy. Wu, X., Kasselouri, A., Vergnaud-Gauduchon, J. and Rosilio, V., 2020. International journal of pharmaceutics, 579, p.119168.
Bioinspired polydopamine nanoparticles: synthesis, nanomechanical properties, and efficient PEGylation strategy. Zmerli, I., Michel, J.P. and Makky, A., 2020. Journal of Materials Chemistry B, 8(20), pp.4489-4504
Green one-step synthesis of medical nanoagents for advanced radiation therapy. Salado-Leza, D., Porcel, E., Yang, X., Štefančíková, L., Bolsa-Ferruz, M., Savina, F., Dragoe, D., Guerquin-Kern, J.L., Wu, T.D., Hirayama, R. and Remita, H., 2020. Nanotechnology, science and applications, pp.61-76
AsiDNA Is a Radiosensitizer with no Added Toxicity in Medulloblastoma Pediatric Models. Clin Cancer Res. Ferreira S, Foray C, Gatto A, Larcher M, Heinrich S, Lupu M, Mispelter J, Boussin FD, Pouponnot C, Dutreix M. Clin Cancer Res. 2020 Nov 1;26(21):5735-5746.
The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal. Kramarz, K., Schirmeisen, K., Boucherit, V. et al. Nat Commun 11, 5643 (2020).
FLASH Irradiation Spares Lung Progenitor Cells and Limits the Incidence of Radio-induced Senescence. Fouillade C, Curras-Alonso S, Giuranno L, Quelennec E, Heinrich S, Bonnet-Boissinot S, Beddok A, Leboucher S, Karakurt HU, Bohec M, Baulande S, Vooijs M, Verrelle P, Dutreix M, Londoño-Vallejo A, Favaudon V. Clin Cancer Res. 2020 Mar 15;26(6):1497-1506.
Targeted Knockout of b-Catenin in Adult Melanocyte Stem Cells Using a Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects. Madeleine Le Coz, Zackie Aktary, Nisamanee Charoenchon, Takahiro Kunisada, and Lionel Larue. Journal of Investigative Dermatology (2020) doi:10.1016/j.jid.2020.08.025
Topoisomerase IIα prevents ultrafine anaphase bridges by two mechanisms. Simon Gemble, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Gaëlle Fontaine, Sarah Lambert and Mounira Amor-Guéret. Open Biol. 10:190259
Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1. Ehlén Å, Martin C, Miron S, Julien M, Theillet FX, Ropars V, Sessa G, Beaurepere R, Boucherit V, Duchambon P, El Marjou A, Zinn-Justin S, Carreira A. Nat Commun. 2020 Apr 14;11(1):1819.
A decrease in NAMPT activity impairs basal PARP‑1 activity in cytidine deaminase deficient‑cells, independently of NAD+. Sandra Cunha Silveira, Géraldine Buhagiar‑Labarchède, Rosine Onclercq‑Delic, Simon Gemble, Elias Bou Samra, Hamza Mameri, Patricia Duchambon, Christelle Machon, Jérôme Guitton & Mounira Amor‑Guéret. Nature (2020) 10:13907
Tubulin polyglutamylation is a general traffic-control mechanism in hippocampal neurons. Bodakuntla S, Schnitzler A, Villablanca C, Gonzalez-Billault C, Bieche I, Janke C, Magiera MM. J Cell Sci 133: jcs241802
Measuring the Impact of Tubulin Posttranslational Modifications on Axonal Transport. Bodakuntla S, Magiera MM, Janke C. Methods Mol Biol 2101: 353-370
Knocking Out Multiple Genes in Cultured Primary Neurons to Study Tubulin Posttranslational Modifications. Bodakuntla S, Janke C, Magiera MM. Methods Mol Biol 2101: 327-351
2019
An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma. Morgane Morabito, Magalie Larcher, Florence MG Cavalli, Chloé Foray, Antoine Forget, Liliana Mirabal-Ortega, Mamy Andrianteranagna, Sabine Druillennec, Alexandra Garancher, Julien Masliah-Planchon, Sophie Leboucher, Abel Debalkew, Alessandro Raso, Olivier Delattre, Stéphanie Puget, François Doz, Michael D Taylor, Olivier Ayrault, Franck Bourdeaut, Alain Eychène, Celio Pouponnot. EMBO Molecular Medicine 11, no 8 (1 août 2019): e9830.
Where do you find us ?
Location
Institut Curie - Centre de Recherche
Multimodal Imaging Center (MIC)
Centre universitaire - Bâtiment 110 - CS90030
Rue Henri Becqurel - 91401 Orsay Cedex
By Car :
By RER :
